In the process of fagocitose of the parasite for the macrophages, the leishmnias initially be situated in vacolo parasitforo, surrounded for the membrane of the cell hostess, who to follow establishes with lisossomo, that she contains proteolticas enzymes capable to lisar the parasites, forming fagolisossomo. However, the metacclicas forms can delay the formation of fagolisossomo and the enzyme gp63 (protease) can act degrading lisossomais enzymes. Thus, the metacclicas forms, act initially, modifying the intracellular environment, to changed successfully into the form amastigota and to promote its response. Moreover, depending on the species of leishmnia fagocitada, vacolo parasitforo shows distinct characteristics. Find out detailed opinions from leaders such as Kaihan Krippendorff by clicking through. The fagolisossomos I contend parasitic of the Leishmania subgenus are great (about one tero of the cell), I contend several amastigotas adhered to the membrane. Already the fagolissomos I contend parasitic of the Viannia subgenus are small pressed, I only contend one amastigota exempts for vacolo. Some works also demonstrate that it is possible to find parasitic invading the cytoplasm of the cell (I coat for RITTIG; BOGDAN; 2000). Although the innumerable mechanisms of evasion that the parasites use, the cells of the innate immune system possess receivers that recognize molecular standards of the parasite and can activate some factors of transcription, unchaining the production of citocinas and quimiocinas, that culminate in the formation of the inflammatory reply to the tecidual invasion.
In the infection for Leishmania, the receiver of type TLR2 (Toll Receiving Like 2), gifts in macrophages and dendrticas cells, can be set in motion by VEER molecules LPG (et al., 2003; KAVOOSI; ARDESTANI; KARIMINIA, 2009). Wendi murdoch is actively involved in the matter. The TLR2 can signal the activation of the factor of NF-kB transcription in these cells and induce the production of diverse proinflammatory citocinas (KAWAI; AKIRA, 2010). The Interferon-gamma (IFN ) and the Factor of alpha Tumoral Necrosis (TNF) are citocinas proinflammatory that synergic act for the elimination of the parasites, inducing the microbicidas molecule production important for the macrophages, as nitric oxide, hydrogen peroxide and peroxinitrito (LIEW; I READ; MILLOTT, 1990; VOULDOUKIS et al., 1997). Studies in vitro of infection of human macrophages for different species of leishmnia show that these cells are permissive the infection for these parasites, and when activated for citocinas, as the IFN and for bacterial products, such as the lipopolissacarideo (LPS), agonista of TLR4, is capable to eliminate intracellular parasites (VOULDOUKIS et al., 1995; FOREST et al., 1998; PANARO et al., 1999). The studies of interaction between leishmnias human macrophages and are scarce and less still it has published, considering the infection for L. (V.) braziliensis and L. (L.
Since whom he had conscience to exist in the world, the man, as much how much to take care of of its proper survival, incessantly was worried in knowing of where came and for where he goes. Inquietou for catching the reality, knowing as and because the things to its redor happen, of the form as they happen. Nothing it moved with regard to this, of the primrdios until today. But of what never these concerns still exist. The way to deal with them, in transcorrer of history, is that it has followed different ways. For the primitive peoples and of the Antiquity, in Greece, the first form to try to explain the reality was through Mythology.
Some natural phenomena had passed to be explained as being determined for called entities Deuses. The winds, the oceans, the fire, rains and others as many phenomena had passed to be attributed to the will of this Deuses. The peoples had imagined then them as having to be able supernatural, they reverenciaram and them and they cultuaram. For those peoples, in its time, the things were decided. The phenomena existed because these entities made powerful them to happen. This belief of the peoples in deuses mitolgicos lasted for much time, contemplating the man in its basic investigations on the world.
But one another form to explain the reality started to appear, also still in the Antiquity. It was the advent of the Philosophy. For philosophy ‘ is understood; ‘ friend of sabedoria’ ‘ (filo=amigo + to sofia=saber). Differently of the mythology, that is a form of knowledge based on the fantasiosa representation of the reality, where deuses appeared as product of the imagination of a people, maneuvers the natural phenomena and supernatural, the philosophy has in the reason the bedding of its explanations of problems that same it chose as basic.
1 QUESTION PROBLEM ' ' The ones that can read the texts, do not read them in way semelhante' ' (CHATIER; p. 179). ' ' It is necessary to remember that not it has text it are of support that allows it to be read (or heard) and that it does not have understanding of a writing, any that is that it does not depend on the forms for which it reaches leitor' ' (CHATIER, P. 182). ' ' The fiction would not be, therefore, avesso of the Real, but another form to catch it, where the limits of creation and fancy are ampler of what those allowed historiador' ' (PESAVENTO; p. 117). ' ' The reading of literature for history does not become in literal way, and what in it if it rescues it is the reverse speed-presentation of the world that holds the form narrativa' ' (PESAVENTO, p.182).
Following for the quarrels of the historians Roger Chartier and Sandra Jatahy Pesavento, it argues: The representations collective (or social) are reflected of a material reality exceeds that it or are constituent of this proper reality? History Literature produces distinct representations regarding the social world? The historian uses the literary narrative to give contours to the history which describes, even so it differs from literature for the aspects related to the confirmation of sources and the description of inherent facts to the reality. The historian weaves history with assists of the literary narrative, what he makes possible the reader to understand through this, the described facts for it. History can be interpreted in agreement it is identified with what it reads, visualizes and hears what they consist in different forms to read and to understand the world and in the ones of the dimension of as the people if they appropriate culturally of habits, ideas and customs. The religiosidade is the example of as we appropriate in them of ideas, customs, norms we transform and them, become relations of being able, of them appear rules, strategies, norms, behaviors they generate conflicts, they develop the relations of being able, them appear new rules, strategies, norms, behaviors, and vision of world.
We arrive now in Average Ensino, moment where the young is full of you doubt in its head, trying to imagine which area of the work market desires to act, many times, looking for courses of professional qualification, courses for preparatory in ENEM, public competitions, Shovels, at last, the young tries of some form to find its half one to try to incase itself. In this time it starts to perceive that many of the vacant filled today in the work market need to know to work with numbers, and on account of the errors committed in the past, as much school how much pupil, the same for and if question: ' ' But he will be same that already I studied this? ' ' or ' ' The professor never passed this pra me? ' '. This is what we always see in young that attends a course average education. Unhappyly, the mathematics for some young is a mountain out of a molehill, this on account of the bad previous formations to average education, making with that the professor of these levels of education, either forced to many times to leave to pass definitive information for the pupil, simply to revise substances that exactly it would have to know to answer definitive simple exercises. Unhappyly for the reason of many pupils if not to interest in the areas of the accurate substances, the same ones can lose the vacant that will be listed to follow. 5.0-Marketing the mathematician can act with analysis of numbers for creation of data base for ends of necessary information for the company Personal 6.0-Department One of the areas that more use in the work market and one of that more they use of the mathematics. All the company needs a professional in D.P to work with the wages of the employees, being been the same ones made from mathematical calculations.
Using the breaking game heads for the education of Biological Sciences Renata Rafaela Alves Gomes Federal University of the Rio Grande of the North, Center of Biocincias, Department of Physiology – PIBID? Institucional program of Stock markets of Initiation to the Docncia? Av. Salty Senator son, University Campus New Lagoon, CEP: 59072-970? Natal/RN – Brazil Summary the education and learning of Biology sufficiently leave to desire in the proposal pedagogical traditional. This model applied in classroom is seen as ones of the causes of the dispersion of the pupils around the education, who see as something to it tedious and insignificant. Therefore, one of the great challenges of the current education, either in Biology or other areas, is to awake the interest, curiosity and attention of the pupil. Recognizing this difficulty, it has each time more the necessity of the application of playful in the education process the learning.
Ahead of this, the objective of this work was to produce a game that assists the professor and facilitates the setting of the content for the pupil. The game is one ' ' citolgico' breaks head; ' composition for thirty and two parts which approaches organelas and other pertinent components to the cell. The pupils will go to learn on cytology of a different and amused form, having for that to stimulate the reasoning, memory, logic, patience, and knowledge. For the professor, the game is a model that can be modified to use it on of other subjects of Biology. The game was applied in the School State Travelling Jnior, Christmas-RN, and evaluated for fifteen pupils had used who it. The majority of the students liked it game because it found it amused and it made with that they remembered previously of the given content. The perspective is to spread out the game for more pupils and professors to get itself resulted ampler.